Tamoxifen # Selective Estrogen Receptor Modulator # SERM # PCT

Tamoxifen is a pharmacological drug acting on estrogen receptors. In medicine, it is often used in the treatment of breast cancers, while in sports it is used to combat gynecomastia - diseases of the chest and mammary glands, as well as in PCT after taking steroids, in order to stimulate the production of body's own testosterone.

Problems arise mainly in athletes after increasing the dosage of testosterone, against the background of liver problems. There are more female hormones in the blood and as a result there is gynecomastia, which is removed with the help of Tamoxifen or surgery.

The antiestrogen Tamoxifen, aka Nolvadex, is often used during post-cycle therapy to increase endogenous testosterone. It actively acts on the whole body, blocking estrogen receptors in its cells. The great demand for it is due to the relatively cheap cost compared to peers, and the ability to use with many other drugs.

Manufacturer

Tamoxifen is produced by various companies in many countries of the world. The most common with us are preparations made by:

Nolvadex Dragon Pharma, Europe

55.00 USD 41.25 USD

Quantity:

Nolvaxyl Kalpa Pharmaceuticals LTD, India

30.00 USD 21.00 USD

Quantity:

Nolvadex Beligas Pharmaceuticals

50.00 USD 45.00 USD

Out of stock

Tamodex Sciroxx

30.00 USD

Out of stock

Cytotam 20 Cipla, India

45.00 USD 40.50 USD

Out of stock

Nolvadex 10 AstraZeneca

25.00 USD 22.50 USD

Out of stock

Nolvadex 20 mg Generic

44.00 USD 39.60 USD

Out of stock

Tamoxi-Lab 7Lab Pharma, Switzerland

29.00 USD

Out of stock

Tamoxifen Citrate Dabur Pharma Ltd, India

43.00 USD 38.70 USD

Out of stock

Tamoximed Balkan Pharmaceuticals

40.00 USD

Out of stock

Tamoxifen Ice Pharmaceuticals

55.00 USD

Out of stock

Tamoxifen was first released in 1962 by British scientists. It was intended for birth control, but was not effective in contraception. After many testing, a positive effect was found on the fight against estrogen-sensitive forms of breast cancer.

As of 2001, sales of Tamoxifen totaled over $ 1 billion. In 2004, this drug was the most in demand in the world for the treatment of breast cancer.

Product Group

Tamoxifen belongs to the antiestrogen group. It does not have gestagenic and androgenic activities, it reduces circulating estrogens, thereby increasing gonadotropin secretions.

Release Forms

Tamoxifen is available in:

tablets (10 mg, 20 mg, 30 mg, 40 mg);

Tamoxifen is an antiestrogen (antimetabolite). It has close contact with estrogens in the cytoplasm of an estrogen-dependent tumor cell. Together with these substances, it penetrates directly into the nucleus, in which it performs the function of blocking the interactions of estrogens with their receptors.

Pharmacokinetics

After oral administration, Tamoxifen instantly disperses throughout the body. The most effective effect is achieved within 4-7 hours.

Tamoxifen interacts well with albumin (serum). During conjugation, demethylation and hydroxylation, many metabolites are formed that contribute to the achievement of therapeutic effects.

Composition

The composition includes tamoxifen citrate, magnesium stearate, lactose, crospovidone and povidone. In one tablet is 30.4 g. tamoxifen citrate.
Indications for use

Tamoxifen is used to treat:

• metastatic breast cancer;
• endometrial cancer;
• early stages of kidney cancer;
• soft tissue sarcomas;
• anovulatory infertility;
• postpartum agalactia;
• oligospermia;
• pituitary tumors.

According to statistics cited by the California Research Center, tamoxifen reduces the risk of breast cancer by 45% compared with patients not taking this drug.

Contraindications

Tamoxifen is completely contraindicated in cases of:

• pregnancy;
• thrombophlebitis;
• hyper sensitivity to the drug;
• leukopenia;
• thrombocytopenia;
• hyperlipidemia;
• hypercalcemia;
• cataracts.

Dosage

Athletes are advised to take Tamoxifen alternately with aromatase inhibitors. Per day, as the main means of administration, it is recommended to take from 10 to 20 mg of Tamoxifen. You should start from the last week of the cycle, finish - in the second week after the course.

Side Effects

Often, side effects are associated with the antiestrogenic properties of Tamoxifen. An overdose or a longer recommended course may result in:

in women - to hair loss, fever, itching, pain in the limbs;

in men - to temperature jumps, nausea, dizziness, blurred vision, diarrhea.

The manifestations of increased fatigue, constipation, anorexia, cataracts, and vision problems are also possible.

Drug Interaction

Excluded from the diet while taking Tamoxifen is recommended secretolytics and antacids. Estrogens weaken the effectiveness of Tamoxifen, progestogens increase.

Cytostatics increase the risk of thrombosis, while the use of Tamoxifen together with other coumarin-type coagulants causes a significant increase in anticoagulant effects.

Storage

Shelf life - 2 years from the date of production. It is strictly forbidden to take Tamoxifen after its release. Store in a dry place, protected from direct sunlight and children, at an air temperature of 16-26 C0.